Dominant Spinocerebellar Ataxia: Genetic Counseling

被引：2

作者：

Jackson, J. F. ^{[1
]}

Currier, R. D. ^{[2
]}

Morton, N. E. ^{[3
]}

机构：

[1] Univ Mississippi, Sch Med, Dept Prevent Med, Div Med Genet, Jackson, MS 39216 USA

[2] Univ Mississippi, Sch Med, Dept Neurol, Jackson, MS 39216 USA

[3] Univ Hawaii, Populat Genet Lab, Honolulu, HI 96822 USA

来源：

JOURNAL OF NEUROGENETICS | 1983年 / 1卷 / 01期

关键词：

dominant spinocerebellar ataxia; olivopontocerebellar atrophies (OPCA); genetic counseling; HLA linkage;

D O I：

10.3109/01677068309107074

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Dominantly inherited spinocerebellar ataxia (OPCA 1) poses a particular problem for genetic counseling due to late age of onset. Liability for disease using observed age of onset can be combined with HLA linkage data to provide revised estimates of risk for affection. Where data is informative, certain combinations may yield estimates which improve so rapidly with age that postponement of childbearing may become a strong consideration as an option.

引用

页码：87 / 90

页数：4

共 7 条

[1]

Jackson J F, 1978, Adv Neurol, V21, P315

[2] SPINOCEREBELLAR ATAXIA AND HLA LINKAGE - RISK PREDICTION BY HLA TYPING [J].

JACKSON, JF ;

CURRIER, RD ;

TERASAKI, PI ;

MORTON, NE .

NEW ENGLAND JOURNAL OF MEDICINE, 1977, 296 (20) :1138-1141

[3]

KOEPPEN AH, 1980, LANCET, V1, P92

[4] OLIVOPONTOCEREBELLAR ATROPHIES - A REVIEW [J].

KONIGSMARK, BW ;

WEINER, LP .

MEDICINE, 1970, 49 (03) :227-+

[5] LINKAGE STUDIES IN SPINOCEREBELLAR ATAXIA [J].

MORTON, NE ;

LALOUEL, JM ;

JACKSON, JF ;

CURRIER, RD ;

YEE, S .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1980, 6 (03) :251-257

[6]

Murphy E. A., 1979, J HOPKINS MED J, V146, P177

[7] FAMILY WITH HEREDITARY ATAXIA - HLA TYPING [J].

NINO, HE ;

NOREEN, HJ ;

DUBEY, DP ;

RESCH, JA ;

NAMBOODIRI, K ;

ELSTON, RC ;

YUNIS, EJ .

NEUROLOGY, 1980, 30 (01) :12-20

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