INVESTIGATION OF THE HUMAN METABOLISM OF ANTIPYRINE USING COUPLED LIQUID-CHROMATOGRAPHY AND NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY OF URINE

被引:38
作者
WILSON, ID
NICHOLSON, JK
HOFMANN, M
SPRAUL, M
LINDON, JC
机构
[1] WELLCOME RES LABS,DEPT PHYS SCI,BECKENHAM BR3 3BS,KENT,ENGLAND
[2] ZENECA PHARMACEUT,DEPT SAFETY MED,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND
[3] UNIV LONDON,BIRKBECK COLL,DEPT CHEM,LONDON WC1H 0PP,ENGLAND
[4] BRUKER ANALYT MESSTECH GMBH,W-7512 RHEINSTETTEN 4,GERMANY
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 617卷 / 02期
关键词
D O I
10.1016/0378-4347(93)80507-Z
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The potential of coupled high-performance liquid chromatography-nuclear magnetic resonance spectroscopy for the detection and identification of drug metabolites has been investigated by direct analysis of human urine collected following administration of antipyrine. This approach provided a rapid method of characterizing the major human urinary metabolites of this drug and promises to be of widespread value in structural studies of xenobiotic metabolites.
引用
收藏
页码:324 / 328
页数:5
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