AUTOIMMUNE VERSUS INFLAMMATORY TYPE-I DIABETES - A CONTROVERSY

被引：49

作者：

KOLB, H

KOLBBACHOFEN, V

ROEP, BO

机构：

[1] LEIDEN UNIV HOSP,DEPT IMMUNOHAEMATOL,2300 RC LEIDEN,NETHERLANDS

[2] LEIDEN UNIV HOSP,BLOOD BANK,2300 RC LEIDEN,NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1995年 / 16卷 / 04期

关键词：

D O I：

10.1016/0167-5699(95)80115-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I (insulin-dependents) diabetes mellitus (IDDM) has long been regarded as resulting from the destruction oi the insulin-producing beta cells in the pancreatic islets of Langerhans by autoreactive T cells. An unorthodox view has since evolved, in which the selective death of beta cells may be due to nonspecific inflammatory attack. This concept has gained considerable support, but may not be sufficient to explain the pathogenesis of IDDM. A recent meeting* examined the apparent controversy between inflammatory and antigen-specific immune mechanisms.

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页码：170 / 172

页数：3

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