HBD-1 - A NOVEL BETA-DEFENSIN FROM HUMAN PLASMA

被引：468

作者：

BENSCH, KW

RAIDA, M

MAGERT, HJ

SCHULZKNAPPE, P

FORSSMANN, WG

机构：

[1] Niedersächsisches Institut für Peptid-Forschung, D-30625 Hannover

来源：

FEBS LETTERS | 1995年 / 368卷 / 02期

关键词：

BETA-DEFENSIN; ANTIMICROBIAL PEPTIDE; HEMOFILTRATE; AMINO ACID SEQUENCE; CDNA;

D O I：

10.1016/0014-5793(95)00687-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate. The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues, It contains six cysteines forming three intramolecular disulfide bonds. The molecular mass of hBD-1 is 3928.6 Da. Cloning of the specific cDNA confirmed the amino acid sequence of the native peptide, hBD-1 shares the nine conserved amino acids characteristic for beta-defensins from respiratory epithelial cells and neutrophils of cattle and chicken leukocytes. hBD-1 is present in nanomolar concentration in human plasma.

引用

页码：331 / 335

页数：5

共 19 条

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