N-MONODESMETHYLDILTIAZEM IS THE PREDOMINANT METABOLITE OF DILTIAZEM IN THE PLASMA OF YOUNG AND ELDERLY HYPERTENSIVES

被引:48
作者
MONTAMAT, SC
ABERNETHY, DR
机构
关键词
D O I
10.1111/j.1365-2125.1987.tb03160.x
中图分类号
R9 [药学];
学科分类号
1007 ;
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页码:185 / 189
页数:5
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共 14 条
[1]   DILTIAZEM AND DESACETYLDILTIAZEM ANALYSIS IN HUMAN-PLASMA USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY - IMPROVED SENSITIVITY WITHOUT DERIVATIZATION [J].
ABERNETHY, DR ;
SCHWARTZ, JB ;
TODD, EL .
JOURNAL OF CHROMATOGRAPHY, 1985, 342 (01) :216-220
[2]  
BENDER DA, 1965, J AM GERIATR SOC, V13, P192
[3]   DILTIAZEM TREATMENT IMPAIRS HEPATIC DRUG OXIDATION - STUDIES OF ANTIPYRINE [J].
CARRUM, G ;
EGAN, JM ;
ABERNETHY, DR .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1986, 40 (02) :140-143
[4]  
HOLFORD NHG, 1982, PUBLIC PROCEDURES S, V1
[5]   ASSESSMENT OF PHARMACOKINETIC CONSTANTS FROM POSTINFUSION BLOOD CURVES OBTAINED AFTER IV INFUSION [J].
LOO, JCK ;
RIEGELMAN, S .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1970, 59 (01) :53-+
[6]   VERAPAMIL PHARMACOKINETICS AND APPARENT HEPATIC AND RENAL BLOOD-FLOW [J].
MEREDITH, PA ;
ELLIOTT, HL ;
PASANISI, F ;
KELMAN, AW ;
SUMNER, DJ ;
REID, JL .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 20 (02) :101-106
[7]   HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF DILTIAZEM AND ITS MAJOR METABOLITES, N-MONODEMETHYLDILTIAZEM AND DESACETYLDILTIAZEM, IN PLASMA [J].
MONTAMAT, SC ;
ABERNETHY, DR ;
MITCHELL, JR .
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1987, 415 (01) :203-207
[8]  
MORSELLI PL, 1978, NEW DRUG THERAPY CAL
[9]   PHARMACOKINETICS OF DILTIAZEM IN SELECTED ANIMAL SPECIES AND HUMAN-BEINGS [J].
PIEPHO, RW ;
BLOEDOW, DC ;
LACZ, JP ;
RUNSER, DJ ;
DIMMIT, DC ;
BROWNE, RK .
AMERICAN JOURNAL OF CARDIOLOGY, 1982, 49 (03) :525-528
[10]  
ROVEI V, 1980, ACTA CARDIOL, V35, P35