ROLE OF PHOSPHORYLASE IN THE INHIBITORY EFFECT OF EDTA AND ATP ON LIVER-GLYCOGEN SYNTHASE PHOSPHATASE

被引：15

作者：

LALOUX, M ^{[1
]}

HERS, HG ^{[1
]}

机构：

[1] CATHOLIC UNIV LOUVAIN,INT INST CELLULAR & MOLEC PATHOL,B-1200 BRUSSELS,BELGIUM

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91778-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The work of Gilboe and Nuttall on the inhibition of liver synthase phosphatase activity by EDTA (J. Biol. Chem., 253, 4078-4081, 1978) and by ATP (Biochim. Biophys. Acta, 338, 57-67, 1974) has been confirmed and extended. It appears that these inhibitory effects are not specific since they can be elicited by other polyvalent anions and that they are transient since they last only as long as phosphorylase a is present. The duration of these inhibitory effects can be shortened by the addition of glucose or caffeine which stimulate phosphorylase phosphatase activity. It is concluded that the inhibitory effects of EDTA and ATP are mediated by phosphorylase a. © 1979.

引用

页码：762 / 768

页数：7

共 12 条

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