GI TRANSIT OF POTENTIAL BIOADHESIVE FORMULATIONS IN MAN - A SCINTIGRAPHIC STUDY

被引：73

作者：

HARRIS, D ^{[1
]}

FELL, JT ^{[1
]}

SHARMA, HL ^{[1
]}

TAYLOR, DC ^{[1
]}

机构：

[1] UNIV MANCHESTER,DEPT PHARM,OXFORD RD,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 12卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

bioadhesion; G.I; transit; gamma scintigraphy; gastric emptying; small intestinal transit time;

D O I：

10.1016/0168-3659(90)90182-S

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is known that the oral availability of certain drugs can be limited by the residence time of the dose in the upper GI tract. Among the methods proposed to delay the transit of oral pharmaceutical formulations is the use of bioadhesion. In this work, the gastric emptying and small intestinal transit of some potentially adhesive formulations were studied in man by gamma scintigraphy. Two different capsule formulations were investigated, in combination with two potentially bioadhesive polymers and a non-adhesive control. Small differences in oro-caecal transit were seen with certain combinations, but no dramatic effects on GI transit were observed. © 1990.

引用

页码：45 / 53

页数：9

共 23 条

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