5-AMINOLEVULINATE SYNTHASE MESSENGER-RNA LEVELS IN THE HARDERIAN-GLAND OF SYRIAN-HAMSTERS - CORRELATION WITH PORPHYRIN CONCENTRATIONS AND REGULATION BY ANDROGENS AND MELATONIN

被引：51

作者：

MENENDEZPELAEZ, A ^{[1
]}

RODRIGUEZ, C ^{[1
]}

DOMINGUEZ, P ^{[1
]}

机构：

[1] UNIV OVIEDO, DEPT BIOL FUNC, E-33006 OVIEDO, SPAIN

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1991年 / 80卷 / 1-3期

关键词：

AMINOLEVULINATE SYNTHASE; GENE; ANDROGEN; MELATONIN; HARDERIAN GLAND; (HAMSTER);

D O I：

10.1016/0303-7207(91)90154-K

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The levels of 5-aminolevulinate synthase mRNA were investigated in the Harderian glands of male and female Syrian hamsters by using a cDNA clone from rat liver. Female hamsters showed higher levels of mRNA than those in males, while the administration of testosterone to female hamsters led to a reduction in mRNA levels. Castration of male hamsters caused a marked elevation of mRNA levels, whereas both the exposure to constant darkness or melatonin injections to castrated males partially prevented the effects of castration. Porphyrin concentration of Harderian glands showed a strong correlation with the mRNA levels of 5-aminolevulinate synthase in all the animals studied. These results lead to the conclusion that in this system, porphyrin metabolism is controlled through hormonal regulation of 5-aminolevulinate synthase gene expression.

引用

页码：177 / 182

页数：6

共 30 条

[1] BROMOCRIPTINE PREVENTS THE CASTRATION-INDUCED RISE IN PORPHYRIN CONCENTRATION IN THE HARDERIAN GLANDS OF THE MALE SYRIAN-HAMSTER, MESOCRICETUS-AURATUS [J].

BUZZELL, GR ;

MENENDEZPELAEZ, A ;

PORKKAHEISKANEN, T ;

PANGERL, A ;

PANGERL, B ;

VAUGHAN, MK ;

REITER, RJ .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1989, 249 (02) :172-176

[2] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[3] EFFECTS OF CASTRATION, BLINDING, AND PINEAL-GLAND ON HARDERIAN GLANDS OF MALE GOLDEN-HAMSTER [J].

CLABOUGH, JW ;

NORVELL, JE .

NEUROENDOCRINOLOGY, 1973, 12 (06) :344-353

[4]

DAVIES LG, 1986, BASIC METHODS MOL BI

[5]

ELFERINK CJ, 1987, J BIOL CHEM, V262, P3988

[6]

GRANICK S, 1966, J BIOL CHEM, V241, P1359

[7] ISOLATION AND CHARACTERIZATION OF FULL-LENGTH CDNA CLONES FOR HUMAN ALPHA-ACTIN, BETA-ACTIN AND GAMMA-ACTIN MESSENGER-RNAS - SKELETAL BUT NOT CYTOPLASMIC ACTINS HAVE AN AMINO-TERMINAL CYSTEINE THAT IS SUBSEQUENTLY REMOVED [J].

GUNNING, P ;

PONTE, P ;

OKAYAMA, H ;

ENGEL, J ;

BLAU, H ;

KEDES, L .

MOLECULAR AND CELLULAR BIOLOGY, 1983, 3 (05) :787-795

[8] INFLUENCE OF SOME ENDOCRINE GLANDS, HORMONES AND BLINDING ON HISTOLOGY AND PORPHYRINS OF HARDERIAN GLANDS OF GOLDEN HAMSTERS [J].

HOFFMAN, RA .

AMERICAN JOURNAL OF ANATOMY, 1971, 132 (04) :463-&

[9] FURTHER-STUDIES ON THE REGULATION OF THE HARDERIAN GLANDS OF GOLDEN-HAMSTERS BY THE THYROID-GLAND [J].

HOFFMAN, RA ;

HABEEB, P ;

BUZZELL, GR .

JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 1990, 160 (03) :269-275

[10]

HOFFMAN RA, 1989, ADV PINEAL RES, V3, P225

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