BRAIN-STEM EXCITATORY AMINO-ACID RECEPTORS IN NOCICEPTION - MICROINJECTION MAPPING AND PHARMACOLOGICAL CHARACTERIZATION OF GLUTAMATE-SENSITIVE SITES IN THE BRAIN-STEM ASSOCIATED WITH ALGOGENIC BEHAVIOR

被引:33
作者
JENSEN, TS
YAKSH, TL
机构
[1] UNIV CALIF SAN DIEGO, DEPT ANESTHESIOL, LA JOLLA, CA 92093 USA
[2] AALBORG HOSP, DEPT NEUROL, DK-9000 AALBORG, DENMARK
关键词
D O I
10.1016/0306-4522(92)90142-O
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In awake, freely moving rats, the intracerebral administration of the excitatory amino acid L-glutamate (30 nmol/0.5-mu-1) into discrete regions of the brainstem resulted in a transient and spontaneous pain-like syndrome characterized by an initial vocalization and vigorous escape behavior. Systematic microinjection mapping studies were carried out at sites distributed caudally from the lower medulla and rostrally into diencephalon. These studies revealed that the spontaneous pain-like behavior was observed to occur after glutamate injection in 13% of 331 microinjected sites, and these sensitive sites were largely limited to the mesencephalic periaqueductal gray matter. The behavioral syndrome was dose-dependent and antagonized in a dose-dependent fashion by the glutamate receptor antagonists MK 801 and DL-2-amino-5 phosphonovalerate but not by gamma-D-glutamyl-amino-methylsulfonic acid. The pain-like behavior was also produced by the other excitatory amino acid receptor agonists N-methyl-D-aspartate, quisqualate and to a certain extent by kainate in a dose-dependent manner with the order of potency being N-methyl-D-aspartate = kainate > quisqualate > D-glutamate. The effects of N-methyl-D-aspartate and quisqualate were antagonized by MK 801 and DL-2-amino-5 phosphonovalerate but not by gamma-D-glutamyl-amino-methylsulfonic acid. It is suggested that the pain-like behavioral syndrome is the result of focal occupation of N-methyl-D-aspartate receptors on neuronal populations in the terminal regions of rostrally projecting spinomesencephalic systems.
引用
收藏
页码:535 / 547
页数:13
相关论文
共 71 条
[1]  
AIMONE LD, 1986, J NEUROSCI, V6, P1803
[2]   PERIAQUEDUCTAL GREY PROJECTION TO THE VENTROBASAL COMPLEX IN THE CAT - AN HORSERADISH-PEROXIDASE STUDY [J].
BARBARESI, P ;
CONTI, F ;
MANZONI, T .
NEUROSCIENCE LETTERS, 1982, 30 (03) :205-209
[3]   EVIDENCE THAT AN EXCITATORY CONNECTION BETWEEN THE PERIAQUEDUCTAL GRAY AND NUCLEUS RAPHE MAGNUS MEDIATES STIMULATION PRODUCED ANALGESIA [J].
BEHBEHANI, MM ;
FIELDS, HL .
BRAIN RESEARCH, 1979, 170 (01) :85-93
[4]   THE ORGANIZATION OF AFFERENT-PROJECTIONS TO THE MIDBRAIN PERIAQUEDUCTAL GRAY OF THE RAT [J].
BEITZ, AJ .
NEUROSCIENCE, 1982, 7 (01) :133-159
[5]   PERIPHERAL AND SPINAL MECHANISMS OF NOCICEPTION [J].
BESSON, JM ;
CHAOUCH, A .
PHYSIOLOGICAL REVIEWS, 1987, 67 (01) :67-186
[6]   THE TERMINATION OF SPINOMESENCEPHALIC FIBERS IN CAT - AN EXPERIMENTAL ANATOMICAL STUDY [J].
BJORKELAND, M ;
BOIVIE, J .
ANATOMY AND EMBRYOLOGY, 1984, 170 (03) :265-277
[7]   ROLE OF RETICULAR-FORMATION IN RESPONSES TO NOXIOUS-STIMULATION [J].
BOWSHER, D .
PAIN, 1976, 2 (04) :361-378
[8]  
CASEY K L, 1971, International Journal of Neuroscience, V2, P29, DOI 10.3109/00207457109146990
[9]  
CASEY K L, 1971, International Journal of Neuroscience, V2, P15, DOI 10.3109/00207457109146989
[10]   SOMATIC STIMULI, SPINAL PATHWAYS, AND SIZE OF CUTANEOUS FIBERS INFLUENCING UNIT ACTIVITY IN MEDIAL MEDULARY RETICULAR FORMATION [J].
CASEY, KL .
EXPERIMENTAL NEUROLOGY, 1969, 25 (01) :35-+