EFFECT OF INTRACEREBRAL INJECTION OF MONOCLONAL ACETYLCHOLINESTERASE ANTIBODIES ON CHOLINERGIC NERVE-TERMINALS IN THE RAT CENTRAL-NERVOUS-SYSTEM

被引：15

作者：

BEAN, AJ ^{[1
]}

XU, Z ^{[1
]}

CHAI, SY ^{[1
]}

BRIMIJOIN, S ^{[1
]}

HOKFELT, T ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT PHARMACOL,ROCHESTER,MN 55905

来源：

NEUROSCIENCE LETTERS | 1991年 / 133卷 / 01期

关键词：

ACETYLCHOLINE; DOPAMINE; ROTATIONAL BEHAVIOR; STRIATUM; TYROSINE HYDROXYLASE; RAT;

D O I：

10.1016/0304-3940(91)90078-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the rat, unilateral intrastriatal injection of monoclonal antibodies to acetylcholinesterase (AChE) produced ipsilateral disappearance of AChE-positive nerve terminals within striatum and adjacent cortex. No alterations in striatal staining patterns were observed for tyrosine hydroxylase, somatostatin, neuropeptide Y, substance P, or neurotensin. Ultrastructural studies demonstrated the presence of degenerating AChE-positive boutons ipsilaterally, while tyrosine hydroxylase positive terminals seemed unaffected. Apomorphine administration to rats which had received unilateral antibody injection resulted in ipsilateral rotational behavior. These data suggest that selective effects on cholinergic terminals with functional deficits can be produced within the central nervous system by intracerebral injection of AChE antibodies.

引用

页码：145 / 149

页数：5

共 26 条

[1] ARE SOLUBLE AND MEMBRANE-BOUND RAT-BRAIN ACETYLCHOLINESTERASE DIFFERENT [J].