THE JUVENILE-HORMONE ANALOG, METHOPRENE, INHIBITS ECDYSTERONE INDUCTION OF SMALL HEAT-SHOCK PROTEIN GENE-EXPRESSION

被引：49

作者：

BERGER, EM ^{[1
]}

GOUDIE, K ^{[1
]}

KLIEGER, L ^{[1
]}

BERGER, M ^{[1
]}

DECATO, R ^{[1
]}

机构：

[1] DARTMOUTH COLL,CTR MOLEC GENET,HANOVER,NH 03755

来源：

DEVELOPMENTAL BIOLOGY | 1992年 / 151卷 / 02期

关键词：

D O I：

10.1016/0012-1606(92)90181-F

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The small heat shock protein (hsp) genes of Drosophila are expressed in cultured cells in response to the moulting hormone, ecdysterone. We show here that juvenile hormone (JHIII) and the juvenile hormone analogue, methoprene, inhibit that induction in a dose-dependent manner. Heat shock induction is not inhibited. In transient expression studies using S3 line cells transfected with EcRE-CAT constructs, methoprene inhibition was found to require a 2-hr pretreatment (before ecdysterone addition), and methoprene's continued presence was essential. Farnesol, farnesyl acetate, and retinoic acid did not cause inhibition. Several models of methoprene inhibition are discussed. © 1992.

引用

页码：410 / 418

页数：9

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