OPIOID HYPEREXCITABILITY - THE APPLICATION OF ALTERNATE OPIOID THERAPY

被引：78

作者：

MACDONALD, N

DER, L

ALLAN, S

CHAMPION, P

机构：

[1] BRITISH COLUMBIA CANC AGCY,VICTORIA V8R IJ8,BC,CANADA

[2] QUEEN ELIZABETH HOSP,CHARLOTTETOWN PEI CIA,PEI,CANADA

来源：

PAIN | 1993年 / 53卷 / 03期

关键词：

HYDROMORPHONE; MORPHINE; PALLIATIVE CARE; CANCER;

D O I：

10.1016/0304-3959(93)90232-E

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Three cases are reported where patients experienced severe central nervous system adverse effects on high-dose hydromorphone. These effects were rapidly alleviated following a change in therapy to morphine at 20-25% of the usually accepted potency equivalent dose. We recommend caution in using equivalent dose tables when changing opioid therapy in patients receiving high-dose opioid treatment.

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收藏

页码：353 / 355

页数：3

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