DISSOLUTION KINETICS OF GRISEOFULVIN IN MIXED MICELLAR SOLUTIONS

被引：13

作者：

DESMIDT, JH ^{[1
]}

GRIT, M ^{[1
]}

CROMMELIN, DJA ^{[1
]}

机构：

[1] UNIV UTRECHT, FAC PHARM, DEPT PHARMACEUT, 3508 TB UTRECHT, NETHERLANDS

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 09期

关键词：

D O I：

10.1002/jps.2600830904

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The dissolution kinetics of the poorly water soluble, lipophilic model drug substance griseofulvin were studied in solutions containing simple and mixed micelles of sodium cholate (BS) and phosphatidylcholine (PC). Variables under investigation were the concentration of BS and the ratio PC/BS. A rotating disk apparatus was used to monitor the dissolution process. With this method, (mixed) micellar diffusion coefficients could be calculated and some detailed information about the physicochemical behavior and composition of mixed PC/BS micelles could be derived.

引用

页码：1209 / 1212

页数：4

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