CONTROL MECHANISMS OF EPSTEIN-BARR-VIRUS PERSISTENCE

被引：8

作者：

LEE, SP

机构：

[1] Cancer Research Campaign Laboratories, Institute of Cancer Studies, University of Birmingham, Birmingham

来源：

SEMINARS IN VIROLOGY | 1994年 / 5卷 / 04期

关键词：

CYTOTOXIC T LYMPHOCYTES; EPSTEIN-BARR VIRUS; PERSISTENCE;

D O I：

10.1006/smvy.1994.1031

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr virus (EBV), a gammaherpesvirus widespread in all human populations, establishes an asymptomatic persistent infection in the majority of individuals. This review briefly summarizes what is known about the complex interactions between the virus and its host, with particular emphasis on the immune mechanisms that are involved in controlling persistent infection. EBV also persists in the malignant cells of a number of human tumors. The possible mechanisms by which these cells might avoid virus-specific immune responses and the potential for adapting these responses to clear the tumor are also discussed.

引用

收藏

页码：281 / 288

页数：8

相关论文

共 46 条

[1] EVIDENCE FOR THE ONTOGENIC PRECEDENCE OF SUPPRESSOR T-CELL FUNCTIONS IN THE HUMAN NEONATE [J].

ANDERSSON, U ;

BRITTON, S ;

DELEY, M ;

BIRD, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1983, 13 (01) :6-13

[2] EPSTEIN-BARR VIRUS (EBV) ANTIGENS PROCESSED AND PRESENTED BY B-CELLS, B-BLASTS, AND MACROPHAGES TRIGGER T-CELL-MEDIATED INHIBITION OF EBV-INDUCED B-CELL TRANSFORMATION [J].

BEJARANO, MT ;

MASUCCI, MG ;

MORGAN, A ;

MOREIN, B ;

KLEIN, G ;

KLEIN, E .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1398-1401

[3] INCREASED SENSITIVITY OF HUMAN LYMPHOID LINES TO NATURAL-KILLER CELLS AFTER INDUCTION OF THE EPSTEIN-BARR VIRAL CYCLE BY SUPER-INFECTION OR SODIUM-BUTYRATE [J].

BLAZAR, B ;

PATARROYO, M ;

KLEIN, E ;

KLEIN, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 151 (03) :614-627

[4] DIFFERENT HLA-B27 SUBTYPES PRESENT THE SAME IMMUNODOMINANT EPSTEIN-BARR-VIRUS PEPTIDE [J].

BROOKS, JM ;

MURRAY, RJ ;

THOMAS, WA ;

KURILLA, MG ;

RICKINSON, AB .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (03) :879-887

[5] EPSTEIN-BARR-VIRUS LATENT GENE-TRANSCRIPTION IN NASOPHARYNGEAL CARCINOMA-CELLS - COEXPRESSION OF EBNA1, LMP1, AND LMP2 TRANSCRIPTS [J].

BROOKS, L ;

YAO, QY ;

RICKINSON, AB ;

YOUNG, LS .

JOURNAL OF VIROLOGY, 1992, 66 (05) :2689-2697

[6] THE SPECIFICITY OF RECOGNITION OF A CYTOTOXIC LYMPHOCYTE-T EPITOPE [J].

BURROWS, SR ;

RODDA, SJ ;

SUHRBIER, A ;

GEYSEN, HM ;

MOSS, DJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (01) :191-195

[7] EPSTEIN-BARR-VIRUS (EBV) GENE-EXPRESSION IN EBV-POSITIVE PERIPHERAL T-CELL LYMPHOMAS [J].

CHEN, CL ;

SADLER, RH ;

WALLING, DM ;

SU, IJ ;

HSIEH, HC ;

RAABTRAUB, N .

JOURNAL OF VIROLOGY, 1993, 67 (10) :6303-6308

[8] INDIVIDUAL TUMORS OF MULTIFOCAL EB VIRUS-INDUCED MALIGNANT-LYMPHOMAS IN TAMARINS ARISE FROM DIFFERENT B-CELL CLONES [J].

CLEARY, ML ;

EPSTEIN, MA ;

FINERTY, S ;

DORFMAN, RF ;

BORNKAMM, GW ;

KIRKWOOD, JK ;

MORGAN, AJ ;

SKLAR, J .

SCIENCE, 1985, 228 (4700) :722-724

[9] EPSTEIN-BARR-VIRUS AND HODGKINS-DISEASE - TRANSCRIPTIONAL ANALYSIS OF VIRUS LATENCY IN THE MALIGNANT-CELLS [J].

DEACON, EM ;

PALLESEN, G ;

NIEDOBITEK, G ;

CROCKER, J ;

BROOKS, L ;

RICKINSON, AB ;

YOUNG, LS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :339-349

[10] HLA-A11 EPITOPE LOSS ISOLATES OF EPSTEIN-BARR-VIRUS FROM A HIGHLY A11+ POPULATION [J].

DECAMPOSLIMA, PO ;

GAVIOLI, R ;

ZHANG, QJ ;

WALLACE, LE ;

DOLCETTI, R ;

ROWE, M ;

RICKINSON, AB ;

MASUCCI, MG .

SCIENCE, 1993, 260 (5104) :98-100

← 1 2 3 4 5 →