FETAL TISSUE DOSAGES OF RETINOIDS - EXPERIMENTAL-STUDY CONCERNING A CASE OF ISOTRETINOIN (ROACCUTAN(R)) ADMINISTRATION AND PREGNANCY

被引：7

作者：

BENIFLA, JL ^{[1
]}

VILLE, Y ^{[1
]}

IMBERT, MC ^{[1
]}

FRYDMAN, R ^{[1
]}

THOMAS, A ^{[1
]}

PONS, JC ^{[1
]}

机构：

[1] HOP ANTOINE BECLERE,DEPT OBSTET & GYNECOL,CLAMART,FRANCE

来源：

FETAL DIAGNOSIS AND THERAPY | 1995年 / 10卷 / 03期

关键词：

RETINOIDS; PLACENTAL BARRIER; TERATOGENICITY;

D O I：

10.1159/000264234

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The authors report the case of a women who took retinoids (Roaccutan(R), isotretinoin) during the first trimester of pregnancy, and a therapeutic abortion was carried out. The interest in this case report lies in the determination of the concentration of isotretinoin and its metabolites (4-oxo-isotretinoin, and tretinoin) in fetal tissues, using high performance liquid chromatography. The findings show the significant transplacental crossing of isotretinoin, an accumulation of 4-oxo-isotretinoin in the liver, and a low concentration of retinoids in the brain of this 4-month-old fetus. The authors emphasize that contraception must be used during retinoid treatment, and 4 weeks after retinoids have been stopped.

引用

页码：189 / 191

页数：3