REGULATION OF SYNTHESIS OF RAT LIVER SERINE DEHYDRATASE BY ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE

The formation of rat liver serine dehydratase was stimulated by the injection of animals with adenosine 3′, 5′-cyclic monophosphate, epinephrine, or glucagon. The enhanced formation of serine dehydratase was sensitive to actinomycin D. An inhibition of the formation of serine dehydratase by glucose could be overcome by adenosine 3′, 5′-cyclic monophosphate or, more effectively, by its dibutyryl derivative. © 1969.