EFFECT OF CHRONIC VARIABLE STRESS ON MONOAMINE RECEPTORS - INFLUENCE OF IMIPRAMINE ADMINISTRATION

被引：51

作者：

MOLINA, VA

VOLOSIN, M

CANCELA, L

KELLER, E

MURUA, VS

BASSO, AM

机构：

[1] Departamento de Farmacología, Facultad de Ciencias Químicas Universidad Nacional de Córdoba, 5016 Córdoba, Sucursal 16

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 35卷 / 02期

关键词：

5-HT[!sub]1[!/sub] sites; Beta-adrenoceptors; Chronic variable stress; Imipramine;

D O I：

10.1016/0091-3057(90)90165-E

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Adult male rats were exposed to a series of unpredictable stressors, a paradigm considered to be a model of experimental depression, with or without concurrent administration of imipramine. One day after the last stress event of the chronic regime, binding of cortical beta-adrenoceptors and the behavioral serotonin (5-HT) syndrome induced by 5-methoxy-N,N,dimethyltryptamine (5-MeODMT) were determined in all the experimental groups. Stressed rats showed an "up-regulation" of cortical beta-adrenergic sites, while similar values to control rats were observed when stressed animals were administered imipramine. Regarding the behavioral 5-HT syndrome, comparable behavioral scores were observed between controls and chronically stressed rats. The combination of chronic exposure to different stressors with imipramine treatment resulted in a significant increase of forepaw treading and Straub tail scores. The probable facilitation of behavioral deficits induced by this scheme of chronic stress and the recovery following concurrent administration of imipramine are discussed. © 1990.

引用

页码：335 / 340

页数：6

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