RESPONSES OF EQUINE TRACHEALIS AND LUNG PARENCHYMA TO METHACHOLINE, HISTAMINE, SEROTONIN, PROSTANOIDS, AND LEUKOTRIENES INVITRO

被引：38

作者：

DOUCET, MY ^{[1
]}

JONES, TR ^{[1
]}

FORDHUTCHINSON, AW ^{[1
]}

机构：

[1] MERCK FROSST CTR THERAPEUT RES,DEPT PHARMACOL,POB 1005,POINTE CLAIRE H9R 4P8,QUEBEC,CANADA

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 1990年 / 68卷 / 03期

关键词：

horse; leukotrienes; lung parenchyma; trachea; U-44069;

D O I：

10.1139/y90-053

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The responses of equine trachealis and lung parenchymal strips to a range of contractile agonists were studied. Equine trachealis responded to methacholine > histamine > serotonin as shown by the maximal responses but failed to respond to either leukotrienes (LT), prostaglandin F(2α), or U-44069. Equine parenchymal strips showed considerable tonal activity and responded to LTD4 ≃ LTC4 > U-44069 = LTE4 > methacholine ≃ histamine ≃ serotonin > prostaglandin F(2α) as determined through pD2 values. Neither the concentration response curve to LTD4 nor the intrinsic tonal activity of the preparations was modified by pretreatment with either atropine or indomethacin, although the maximal response to LTD4 was reversed by addition of the LTD4 receptor antagonist, MK-571. Thus arachidonic acid metabolites, including LTs, must be considered potential mediators of equine small airway disease, a potential model of human bronchial asthma.

引用

页码：379 / 383

页数：5

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