REGIONAL DIFFERENCES IN THE PROSTATE OF THE NEONATALLY ESTROGENIZED MOUSE

被引:73
作者
PYLKKANEN, L [1 ]
SANTTI, R [1 ]
NEWBOLD, R [1 ]
MCLACHLAN, JA [1 ]
机构
[1] NIEHS,REPROD & DEV TOXICOL LAB,RES TRIANGLE PK,NC 27709
关键词
NEONATAL ESTROGENIZATION; ESTROGEN RECEPTORS; METAPLASIA; DYSPLASIA;
D O I
10.1002/pros.2990180204
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Neonatal estrogenization of the mouse with diethylstilbestrol resulted in time-of-exposure and dose-dependent inhibition of the growth of the prostatic lobes observed at the age of 2 mon. The critical time was the days 1- 6 of postnatal life. In neonatally estrogenized (neoDES) mice, responses to 5-alpha-dihydrotestosterone in terms of nuclear H-3-thymidine labelling were altered concomitantly with the inhibition of growth and were in accordance with changes in the relative volumes of epithelium, glandular lumina, and interacinar stroma. Secondary estrogen treatment of neoDES mice with 17-beta-estradiol did not increase H-3-thymidine labelling in the prostate of control or neoDES mice. However, it induced squamous epithelial metaplasia in periurethral collecting ducts and proximal parts of coagulating glands of neoDES animals. In control mice only slight epithelial hyperplasia could be observed after similar treatment. Estrogen receptors, located immunocytochemically in nuclei of stromal cell, corresponded with the sites of increased estrogen sensitivity, observed as metaplastic transformation. When the neoDES animals aged, epithelial hyperplasia and dysplasia could be observed at distinct prostatic sites, ie, the periurethral collecting ducts and the coagulating glands and periurethral glands, and stromal inflammation become more extensive. Almost identical location of the epithelial changes and the altered estrogen response is suggestive of causal relationship.
引用
收藏
页码:117 / 129
页数:13
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