SEASONALITY OF HIP FRACTURE AND HEMORRHAGIC-DISEASE OF THE NEWBORN

被引:12
作者
DOUGLAS, AS
机构
[1] Department Medicine and Therapeutics, Medical School, Foresterhill
关键词
D O I
10.1177/003693309303800202
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The objective is to examine and compare the seasonalities of fractured neck of femur and haemorrhagic disease of the newborn. The data are from two sources. Admissions for fractured neck of femur in Scotland over five years (1983-87) are examined by age, sex, mortality, operative intervention and source of admission. Data from the United States (1927-36) are examined for infant death rates from suspected haemorrhagic disease of the newborn 3-14 days after birth. The sine curves are examined. The rhythms, while not identical, have similarities. The peaks are in January-February and the troughs in July-August. Amongst hip fractures the peak is one month earlier and the seasonal excess around 20-25 per cent in both conditions. Rickets, haemorrhagic disease of the newborn and fractured neck of femur have comparable seasonal rhythms. Vitamin D regulates the synthesis of the vitamin K dependent bone protein osteocalcin, which is functionally abnormal in postmenopausal women. This may be a significant factor in the seasonal variation of hip fracture.
引用
收藏
页码:37 / 40
页数:4
相关论文
共 30 条
[1]  
ABALLI AJ, 1977, LANCET, V2, P559
[2]  
BASTOW MD, 1983, LANCET, V1, P143
[3]   EFFECT OF SEASON ON PHYSICAL-ACTIVITY SCORE, BACK EXTENSOR MUSCLE STRENGTH, AND LUMBAR BONE-MINERAL DENSITY [J].
BERGSTRALH, EJ ;
SINAKI, M ;
OFFORD, KP ;
WAHNER, HW ;
MELTON, LJ .
JOURNAL OF BONE AND MINERAL RESEARCH, 1990, 5 (04) :371-377
[4]  
BLANCHARD RA, 1983, BLOOD S, V62, pA272
[5]   VITAMIN-D STATUS IN THE ELDERLY - SEASONAL SUBSTRATE DEFICIENCY CAUSES 1,25-DIHYDROXYCHOLECALCIFEROL DEFICIENCY [J].
BOUILLON, RA ;
AUWERX, JH ;
LISSENS, WD ;
PELEMANS, WK .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1987, 45 (04) :755-763
[6]   EFFECT OF VITAMIN-D SUPPLEMENTATION ON WINTERTIME AND OVERALL BONE LOSS IN HEALTHY POSTMENOPAUSAL WOMEN [J].
DAWSONHUGHES, B ;
DALLAL, GE ;
KRALL, EA ;
HARRIS, S ;
SOKOLL, LJ ;
FALCONER, G .
ANNALS OF INTERNAL MEDICINE, 1991, 115 (07) :505-512
[7]   SEASONALITY OF DISEASE IN KUWAIT [J].
DOUGLAS, AS ;
ALSAYER, H ;
RAWLES, JM ;
ALLAN, TM .
LANCET, 1991, 337 (8754) :1393-1397
[8]  
Halberg F, 1972, PHYSIOL TEACH, V1, P1
[9]   CIRCULATING VITAMIN-K1 LEVELS IN FRACTURED NECK OF FEMUR [J].
HART, JP ;
CATTERALL, A ;
DODDS, RA ;
KLENERMAN, L ;
SHEARER, MJ ;
BITENSKY, L ;
CHAYEN, J .
LANCET, 1984, 2 (8397) :283-283
[10]   DIRECT IDENTIFICATION OF CALCIUM-BINDING AMINO-ACID, GAMMA-CARBOXYGLUTAMATE, IN MINERALIZED TISSUE [J].
HAUSCHKA, PV ;
LIAN, JB ;
GALLOP, PM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :3925-3929