CHAGAS-DISEASE DIAGNOSIS - EVALUATION OF SEVERAL TESTS IN BLOOD-BANK SCREENING

被引:67
作者
CARVALHO, MR
KRIEGER, MA
ALMEIDA, E
OELEMANN, W
SHIKANAIYASSUDA, MA
FERREIRA, AW
PEREIRA, JB
SAEZALQUEZAR, A
DORLHIACLLACER, PE
CHAMONE, DF
GOLDENBERG, S
机构
[1] FUNDACAO OSWALDO CRUZ, DEPT BIOQUIM & BIOL MOLEC, GENE EXPRESS LAB, AVE BRASIL 4365, BR-21045 RIO DE JANEIRO, BRAZIL
[2] FUNDACAO PRO SANGUE HEMOCENTRO SAO PAULO, DEPT SEROL, SAO PAULO, BRAZIL
[3] FUNDACAO OSWALDO CRUZ, DEPT MED TROP, RIO DE JANEIRO, BRAZIL
[4] UNIV SAO PAULO, HOSP CLIN, DEPT MOLESTIAS INFECCIOSAS & PARASITARIAS, SAO PAULO, BRAZIL
[5] UNIV SAO PAULO, HOSP CLIN, DEPT MED TROP, SAO PAULO, BRAZIL
关键词
D O I
10.1046/j.1537-2995.1993.331094054620.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Blood transfusion is one of the principal routes of transmission of Chagas' disease, a major endemic disease in Latin America. Methods for blood screening are not accurate and may yield false results that lead to high social and economic costs. This study compares two methods of diagnosing Chagas' disease (indirect immunofluorescence and hemagglutination) and several enzyme-linked immunosorbent assays (ELISAs) with regard to specificity and sensitivity, by using human sera with known serologic and parasitologic characteristics, as well as samples with discrepant results on conventional serologic tests. An ELISA using recombinant antigens showed no cross-reactivity with sera that were positive for other diseases. All evaluated ELISAs performed well, and their use may lead to a reduction of more than 50 percent in the number of discordant sera. Further improvements are needed in view of the complexity of the serologic diagnosis of Chagas' disease.
引用
收藏
页码:830 / 834
页数:5
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