LIPID-PEROXIDATION IN EARLY EXPERIMENTAL DIABETES IN RATS - EFFECTS OF DIABETES AND INSULIN

被引:28
作者
RUNGBY, J
FLYVBJERG, A
ANDERSEN, HB
NYBORG, K
机构
[1] AARHUS UNIV,INST ANAT,DEPT NEUROBIOL,DK-8000 AARHUS,DENMARK
[2] AARHUS KOMMUNE HOSP,INST EXPTL CLIN RES,DK-8000 AARHUS,DENMARK
来源
ACTA ENDOCRINOLOGICA | 1992年 / 126卷 / 04期
关键词
D O I
10.1530/acta.0.1260378
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The degree of lipid peroxidation was measured in organs from diabetic rats receiving no treatment, and in those from insulin-treated diabetic rats and controls. Lipid peroxidation was measured as organ content of malondialdehyde, a degradation product of polyunsaturated fatty acids. In the kidney, lipid peroxidation was increased after one week of diabetes; insulin treatment reduced the level of lipid peroxidation to levels lower than seen in controls. In the liver, diabetes caused an increased lipid peroxidation. which could be reversed by insulin; no additional effect of insulin was found. In heart and pancreas no effects of diabetes or insulin were demonstrated. The present paper provides evidence that lipid peroxidation is increased in the early stages of experimental diabetes and is reversible by insulin treatment. Hyperinsulinaemia may, in itself, counteract lipid peroxidation in kidney.
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页码:378 / 380
页数:3
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