CENTRALLY-ADMINISTERED GLYCINE ANTAGONISTS INCREASE LOCOMOTION IN MONOAMINE-DEPLETED MICE

被引：24

作者：

SLUSHER, BS

RISSOLO, KC

JACKSON, PF

PULLAN, LM

机构：

[1] ZENECA Pharmaceuticals Group, Department of Pharmacology, CNS Section, Wilmington, DE

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1994年 / 97卷 / 03期

关键词：

RESERPINE; ALPHA-METHYL-PARA-TYROSINE; PARKINSONS DISEASE; GLUTAMATE; DOPAMINE; NMDA RECEPTORS; GLYCINE;

D O I：

10.1007/BF02336139

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of akinesia when administered intrastriatally to monoamine depleted mice. Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation. In addition, all glycine antagonists tested did not cause significant locomotor stimulation when intrastriatally administered to normal mice. These data suggest that glycine antagonists may offer therapeutic utility in the treatment of idiopathic Parkinson's disease.

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收藏

页码：175 / 185

页数：11

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