COMPARISON OF THE POSITIONAL CLONING METHODS USED TO ISOLATE THE BRCA1 GENE

被引：14

作者：

HARSHMAN, K

BELL, R

ROSENTHAL, J

KATCHER, H

MIKI, Y

SWENSON, J

GHOLAMI, Z

FRYE, C

DING, W

DAYANANTH, P

EDDINGTON, K

NORRIS, FH

BRISTOW, PK

PHELPS, R

HATTIER, T

STONE, S

SHAFFER, D

BAYER, S

HUSSEY, C

TRAN, T

RICHARDSON, K

DEHOFF, B

LAI, M

ROSTECK, PR

SKOLNICK, MH

SHATTUCKEIDENS, D

KAMB, A

机构：

[1] UNIV UTAH,MED CTR,DEPT MED INFORMAT,SALT LAKE CITY,UT 84132

[2] ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,INDIANAPOLIS,IN 46285

来源：

HUMAN MOLECULAR GENETICS | 1995年 / 4卷 / 08期

关键词：

D O I：

10.1093/hmg/4.8.1259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A critical step in positional cloning is the identification of candidate genes from a large, genetically defined region, Candidate gene isolation by hybrid selection, genomic sequencing, and direct cDNA library screening identified 45 candidate gene fragments (CGFs) from a 600 kb genomic region that contains the BRCA1 gene, These CGFs define a minimum of 15 genes, six of which are newly localized to the BRCA1 region, We present an analysis of the efficiency and the sequences generated for each of these methods, We also compare our CGF set to those reported for the BRCA1 region by three other groups, revealing a surprising lack of overlap among the sets.

引用

页码：1259 / 1266

页数：8

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