PERSISTENT METRONIDAZOLE-INDUCED PERIPHERAL NEUROPATHY

被引：28

作者：

BOYCE, EG ^{[1
]}

COOKSON, ET ^{[1
]}

BOND, WS ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,PHILADELPHIA,PA 19107

来源：

DICP-THE ANNALS OF PHARMACOTHERAPY | 1990年 / 24卷 / 01期

关键词：

D O I：

10.1177/106002809002400103

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We report the case of a young woman with Crohn's disease who developed a debilitating peripheral neuropathy when treated with metronidazole 2000 mg/d for 50 days. The patient's neuropathy improved considerably after the discontinuation of metronidazole, but still persists two years later. The current literature on this topic is reviewed. Reports such as this one underscore the need to closely monitor the neurologic status of patients undergoing chronic treatment with metronidazole.

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页码：19 / 21

页数：3

相关论文

共 19 条

[1] SIDE-EFFECTS OF DRUGS - DRUG-INDUCED PERIPHERAL NEUROPATHIES [J].

ARGOV, Z ;

MASTAGLIA, FL .

BMJ-BRITISH MEDICAL JOURNAL, 1979, 1 (6164) :663-666

[2]

ASBURY AK, 1987, HARRISONS PRINCIPLES, P2058

[3] ENCEPHALOPATHY WITH METRONIDAZOLE IN A CHILD [J].

BAILES, J ;

WILLIS, J ;

PRIEBE, C ;

STRUB, R .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1983, 137 (03) :290-291

[4] METRONIDAZOLE NEUROPATHY [J].

BRADLEY, WG ;

KARLSSON, IJ ;

RASSOL, CG .

BRITISH MEDICAL JOURNAL, 1977, 2 (6087) :610-611

[5]

BRANDT LJ, 1982, GASTROENTEROLOGY, V83, P383

[6] METRONIDAZOLE NEUROPATHY [J].

COXON, A ;

PALLIS, CA .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1976, 39 (04) :403-405

[7] PERIPHERAL NEUROPATHY IN CROHNS-DISEASE PATIENTS TREATED WITH METRONIDAZOLE [J].

DUFFY, LF ;

DAUM, F ;

FISHER, SE ;

SELMAN, J ;

VISHNUBHAKAT, SM ;

AIGES, HW ;

MARKOWITZ, JF ;

SILVERBERG, M .

GASTROENTEROLOGY, 1985, 88 (03) :681-684

[8] NEUROLOGIC TOXICITY ASSOCIATED WITH HIGH-DOSE METRONIDAZOLE THERAPY [J].

FRYTAK, S ;

MOERTEL, CG ;

CHILDS, DS ;

ALBERS, JW .

ANNALS OF INTERNAL MEDICINE, 1978, 88 (03) :361-362

[9] INTRAVENOUS METRONIDAZOLE FOR TREATMENT OF INFECTIONS INVOLVING ANAEROBIC-BACTERIA [J].

GEORGE, WL ;

KIRBY, BD ;

SUTTER, VL ;

WHEELER, LA ;

MULLIGAN, ME ;

FINEGOLD, SM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 21 (03) :441-449

[10] METRONIDAZOLE NEUROPATHY [J].

HISHON, S ;

PILLING, J .

BRITISH MEDICAL JOURNAL, 1977, 2 (6090) :832-832