EVALUATION OF LANOLIN ALCOHOL FILMS AND KINETICS OF TRIAMCINOLONE ACETONIDE RELEASE

被引：11

作者：

IYER, BV ^{[1
]}

VASAVADA, RC ^{[1
]}

机构：

[1] UNIV PACIFIC,SCH PHARM,STOCKTON,CA 95211

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 06期

关键词：

Dosage forms; topical—lanolin alcohol films; kinetics of triamcinolone acetonide release; Glucocorticoids—triamcinolone acetonide; release from lanolin alcohol films; kinetics; Lanolin alcohol—films; topical dosage forms; Triamcinolone acetonide—release from lanolin alcohol films;

D O I：

10.1002/jps.2600680631

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The film‐forming potential of lanolin alcohol was evaluated. Inclusion of ethylcellulose in lanolin alcohol improved film integrity. The hardness and modulus of elasticity of these lanolin alcohol‐ethylcellulose films were improved by incorporating propylene glycol or cetyl alcohol. Triamcinolone acetonide release from selected film compositions was investigated. The data were analyzed from the viewpoint of the first‐order kinetic theory and the release from a planar system having a homogeneous or granular matrix. The results suggest that the drug release follows a diffusion‐controlled matrix model and a square root of time release profile. The release rate constants were proportional to drug concentration. Drug release was maximal from a system containing the drug in a near‐saturated solution. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：782 / 787

页数：6

共 20 条

[1]

APPLEZWEIG N, 1970, Patent No. 3536809

[2] DRUG RELEASE FROM HYDROXYPROPYL CELLULOSE-POLYVINYL ACETATE FILMS [J].