COULD NONSTEROIDAL ANTIINFLAMMATORY DRUGS BE USED TO POTENTIATE LMWH ACTIVITY IN THROMBOSIS .1.

被引：7

作者：

DOUTREMEPUICH, C

LALANNE, MC

DOUTREMEPUICH, F

FRANCOIS, C

DOSQUE, JP

SASSOUST, G

机构：

[1] Laboratoire d'Hématologie, F33076 Bordeaux cedex

来源：

THROMBOSIS RESEARCH | 1991年 / 63卷 / 01期

关键词：

VENOUS THROMBOSIS; HEPARIN FRACTION; PHENYLBUTAZONE;

D O I：

10.1016/0049-3848(91)90265-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heparin fractions are antithrombotic drugs prescribed for preventive treatment but their efficacy must be optimized to permit curative use without side effects. The present study was performed on 144 rats receiving a low molecular weight heparin (L.M.W.H), Fraxiparine(R), and a non steroidal anti-inflammatory drug (Phenylbutazone(R)), which were injected simultaneously or separately. Neither Phenylbutazone(R) nor L.M.W.H at their lowest dose (1 mg/kg) reduced thrombus size. However, administered together, they produced a significant limitation of thrombus growth. Variation in anti Xa activity limitation was only observed with the highest dose of Fraxiparine(R) alone or in combination with Phenylbutazone(R) (1 mg/kg) corresponding to its antithrombotic effect.

引用

页码：13 / 19

页数：7

共 12 条

[1]

BONEU B, 1986, ANGIOLOGIE, V38, P133

[2]

DOUTREMEPUICH C, 1987, HAEMOSTASIS, V17, P201

[3] THE TPA-LIKE ACTIVITY INDUCED BY HEPARIN AND A HEPARIN FRAGMENT BINDS ON EXPERIMENTAL THROMBUS [J].