ALDEHYDE REDUCTASE IS A MAJOR PROTEIN ASSOCIATED WITH 3-DEOXYGLUCOSONE REDUCTASE-ACTIVITY IN RAT, PIG AND HUMAN LIVERS

被引：54

作者：

KANAZU, T

SHINODA, M

NAKAYAMA, T

DEYASHIKI, Y

HARA, A

SAWADA, H

机构：

[1] GIFU COLL PHARM, DEPT BIOCHEM, MITAHORA HIGASHI, GIFU 502, JAPAN

[2] GIHOKU GEN HOSP, TAKATOMI, GIFU 50121, JAPAN

来源：

BIOCHEMICAL JOURNAL | 1991年 / 279卷

关键词：

D O I：

10.1042/bj2790903

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3-Deoxyglucosone reductase activity in the extracts of rat, pig and human livers was potently inhibited by aldehyde reductase inhibitors. The major species of 3-deoxyglucosone reductase purified from human and pig livers were biochemically and immunochemically identical with aldehyde reductase. The two enzymes and rat liver aldehyde reductase exhibited higher catalytic efficiency for 3-deoxyglucosone than for D-glucuronate, a representative substrate of aldehyde reductase.

引用

页码：903 / 906

页数：4

共 32 条

[1] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[2] PROPERTIES OF AN ALDOSE REDUCTASE FROM PIG LENS - COMPARATIVE STUDIES OF AN ALDEHYDE REDUCTASE FROM PIG LENS
BRANLANT, G
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1982, 129 (01): : 99 - 104
[3] EBLE AS, 1983, J BIOL CHEM, V258, P9406
[4] FELSTED RL, 1974, J BIOL CHEM, V249, P3672
[5] MAMMALIAN CARBONYL REDUCTASES
FELSTED, RL
BACHUR, NR
[J]. DRUG METABOLISM REVIEWS, 1980, 11 (01) : 1 - 60
[6] RAT-LIVER ALDEHYDE REDUCTASE
FELSTED, RL
RICHTER, DR
BACHUR, NR
[J]. BIOCHEMICAL PHARMACOLOGY, 1977, 26 (12) : 1117 - 1124
[7] ALDEHYDE REDUCTASES - MONOMERIC NADPH-DEPENDENT OXIDOREDUCTASES WITH MULTIFUNCTIONAL POTENTIAL
FLYNN, TG
[J]. BIOCHEMICAL PHARMACOLOGY, 1982, 31 (17) : 2705 - 2712
[8] ISOLATION FROM PIG LENS OF 2 PROTEINS WITH DIHYDRODIOL DEHYDROGENASE AND ALDEHYDE REDUCTASE ACTIVITIES
HARA, A
HARADA, T
NAKAGAWA, M
MATSUURA, K
NAKAYAMA, T
SAWADA, H
[J]. BIOCHEMICAL JOURNAL, 1989, 264 (02) : 403 - 407
[9] ISOLATION OF PROTEINS WITH CARBONYL REDUCTASE-ACTIVITY AND PROSTAGLANDIN-9-KETOREDUCTASE ACTIVITY FROM CHICKEN KIDNEY
HARA, A
DEYASHIKI, Y
NAKAGAWA, M
NAKAYAMA, T
SAWADA, H
[J]. JOURNAL OF BIOCHEMISTRY, 1982, 92 (06) : 1753 - 1762
[10] INHIBITION OF DIMERIC DIHYDRODIOL DEHYDROGENASES OF RABBIT AND PIG LENS BY ASCORBIC-ACID
HARA, A
SHINODA, M
KANAZU, T
NAKAYAMA, T
DEYASHIKI, Y
SAWADA, H
[J]. BIOCHEMICAL JOURNAL, 1991, 275 : 121 - 126

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