SYNTHESIS OF A NEW CLASS OF URIDINE PHOSPHORYLASE INHIBITORS

被引：25

作者：

LEVESQUE, DL

WANG, EC

WEI, DC

TZENG, CC

PANZICA, RP

NAGUIB, FNM

ELKOUNI, MH

机构：

[1] UNIV RHODE ISL,DEPT CHEM,KINGSTON,RI 02881

[2] KAOHSIUNG MED COLL,SCH CHEM & PHARM,KAOHSIUNG 807,TAIWAN

[3] UNIV ALABAMA,DEPT PHARMACOL,BIRMINGHAM,AL 35294

[4] UNIV ALABAMA,CTR COMPREHENS CANC,BIRMINGHAM,AL 35294

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 05期

关键词：

D O I：

10.1002/jhet.5570300537

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of potent uridine phosphorylase inhibitors have been prepared from barbituric acid. Among them, 1-[(2-hydroxyethoxy)methyl]-5(m-benzyloxy)benzylbarbituric acid (37, BBBA) is the most promising having a K-i value of 1.1 +/- 0.2 nM with uridine phosphorylase from human liver. The new inhibitors are easily synthesized and are better inhibitors of human uridine phosphorylase than their uracil counterparts.

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页码：1399 / 1404

页数：6

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