FOLLICLE-STIMULATING-HORMONE CONCENTRATIONS IN RELATION TO ACTIVE AND PASSIVE SMOKING

被引:86
作者
COOPER, GS
BAIRD, DD
HULKA, BS
WEINBERG, CR
SAVITZ, DA
HUGHES, CL
机构
[1] NIEHS, STAT & BIOMATH BRANCH, RES TRIANGLE PK, NC 27709 USA
[2] UNIV N CAROLINA, DEPT EPIDEMIOL, CHAPEL HILL, NC USA
[3] DUKE UNIV, MED CTR, DEPT OBSTET & GYNECOL, DURHAM, NC USA
关键词
D O I
10.1016/0029-7844(94)00381-M
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine the association between various forms of tobacco exposure and ovarian status, as measured by FSH concentrations, in women 38-49 years old. Methods: Two hundred ninety women between 38-49 years old, who had not had hysterectomy or oophorectomy, completed a self-administered questionnaire that included information on tobacco exposure and had serum FSH levels measured on days 2-4 of the menstrual cycle. Linear regression was used to assess the relation between FSH and tobacco exposure. Results: Controlling for age and other factors, FSH concentrations were 66% higher among current smokers (geometric mean FSH 14.0 mIU/mL) and 39% higher among nonsmokers with passive smoke exposure (11.7 mIU/mL), compared to nonsmoking women without passive smoke exposure (8.4 mIU/mL). The estimated increase in FSH for each year of age was greater for current smokers than for nonsmokers (16 versus 6%, respectively). Ex-smokers did not have higher FSH concentrations, and there was no association between prenatal exposure to tobacco smoke and FSH. Conclusion: Both active and passive smoking are associated with elevated FSH concentrations in women 38-49 years old. The effect, limited to women with current exposure, is consistent with a shorter duration of the menopausal transition period.
引用
收藏
页码:407 / 411
页数:5
相关论文
共 22 条
  • [1] CIGARETTE-SMOKING AND THE AGE AT MENOPAUSE
    ADENA, MA
    GALLAGHER, HG
    [J]. ANNALS OF HUMAN BIOLOGY, 1982, 9 (02) : 121 - 130
  • [2] COOPER GS, 1994, IN PRESS FERTIL STER, P62
  • [3] CRAMER DW, 1989, FERTIL STERIL, V51, P609
  • [4] DETERMINANTS OF BASAL FOLLICLE-STIMULATING-HORMONE LEVELS IN PREMENOPAUSAL WOMEN
    CRAMER, DW
    BARBIERI, RL
    XU, HJ
    REICHARDT, JKV
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (04) : 1105 - 1109
  • [5] EVERSON RB, 1980, LANCET, V2, P123
  • [6] EFFECT OF PASSIVE EXPOSURE TO SMOKING ON AGE AT NATURAL MENOPAUSE
    EVERSON, RB
    SANDLER, DP
    WILCOX, AJ
    SCHREINEMACHERS, D
    SHORE, DL
    WEINBERG, C
    [J]. BRITISH MEDICAL JOURNAL, 1986, 293 (6550) : 792 - 792
  • [7] Jarrell J, 1988, Reprod Toxicol, V2, P111, DOI 10.1016/0890-6238(88)90006-8
  • [8] JICK H, 1977, LANCET, V1, P1354
  • [9] LINDQUIST O, 1979, ACTA MED SCAND, V205, P73
  • [10] MARCUS M, 1993, FERTIL STERIL, V59, P931