STERIC PARAMETERS IN DRUG DESIGN . MONOAMINE OXIDASE INHIBITORS AND ANTIHISTAMINES

被引：220

作者：

KUTTER, E

HANSCH, C

机构：

[1] Department of Chemistry, Pomona College, California 91711, Claremont

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 04期

关键词：

D O I：

10.1021/jm00304a020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Taft's Es parameter is employed to correlate structure-activity relationships in phenoxyethylcyclopropylamine monoamine oxidase inhibitors and diphenhydramine antihistamines. New Es, values for the halogens and certain other functions have been calculated from van der Waals radii using an extension of the approach suggested by Charton. © 1969, American Chemical Society. All rights reserved.

引用

页码：647 / &

共 34 条

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[5] ANDREWS LJ, 1964, MOLECULAR COMPLEXES, P94
[6] ARIENS EJ, 1964, MOLECULAR PHARMACOLO, P230
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[9] NATURE OF ORTHO EFFECT .2. COMPOSITION OF TAFT STERIC PARAMETERS
CHARTON, M
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (03) : 615 - &
[10] APPLICATION OF HAMMETT EQUATION TO SUBSTITUENT EFFECTS ON PI DONORS IN CHARGE-TRANSFER COMPLEX FORMATION .I. SINGLY SUBSTITUTED DONORS
CHARTON, M
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1966, 31 (09) : 2991 - &

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