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C-26 STEROL IN A HUMAN-URINE

被引：8
作者：
IKEKAWA, N
FUJIMOTO, Y
ISHIGURO, M
SUWA, S
HIRAYAMA, Y
MIZUNUMA, H
机构：
[1] KANAGAWA CHILDRENS MED CTR,DEPT PEDIATR,ENDOCRINOL SECT,MINAMI KU,YOKOHAMA 232,JAPAN
[2] TOKYO HOSP JAPAN,MONOPOLY CORP,MINATO KU,TOKYO 108,JAPAN
来源：
SCIENCE | 1979年 / 204卷 / 4398期
关键词：
D O I：
10.1126/science.451568
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A new C26 sterol, 22-trans-27-norcholesta-5,22-dien-3β-ol, was found in the urine of a 6-year-old girl, with a clinical diagnosis of congenital adrenal hyperplasia of the salt losing type, accompanied by symptoms of mixed sex anatomy and skin pigmentation. The structure of the sterol was determined by comparison with the synthetic compound. The sterol was also detected in the serum. This appears to be the first case in which a C 26 sterol has occurred in mammalia. Copyright © 1979 AAAS.
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页码：1223 / 1224
页数：2
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