AN ERYTHROID SPECIFIC ENHANCER UPSTREAM TO THE GENE ENCODING THE CELL-TYPE SPECIFIC TRANSCRIPTION FACTOR-GATA-1

被引：77

作者：

NICOLIS, S

BERTINI, C

RONCHI, A

CROTTA, S

LANFRANCO, L

MORONI, E

GIGLIONI, B

OTTOLENGHI, S

机构：

[1] UNIV MILAN, DIPARTIMENTO GENET & BIOL MICRORGANISMI, I-20122 MILAN, ITALY

[2] UNIV TURIN, DIPARTIMENTO GENET BIOL & CHIM MED, I-10124 TURIN, ITALY

[3] CNR, CTR STUD PATOL CELLULARE, I-20133 MILAN, ITALY

来源：

NUCLEIC ACIDS RESEARCH | 1991年 / 19卷 / 19期

关键词：

D O I：

10.1093/nar/19.19.5285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.

引用

页码：5285 / 5291

页数：7

共 31 条

[1] ABSOLUTE MESSENGER-RNA QUANTIFICATION USING THE POLYMERASE CHAIN-REACTION (PCR) - A NOVEL-APPROACH BY A PCR AIDED TRANSCRIPT TITRATION ASSAY (PATTY)
BECKERANDRE, M
HAHLBROCK, K
[J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (22) : 9437 - 9446
[2] PURIFICATION AND BIOCHEMICAL-CHARACTERIZATION OF THE PROMOTER-SPECIFIC TRANSCRIPTION FACTOR, SPL
BRIGGS, MR
KADONAGA, JT
BELL, SP
TJIAN, R
[J]. SCIENCE, 1986, 234 (4772) : 47 - 52
[3] PROGRESSIVE INACTIVATION OF THE EXPRESSION OF AN ERYTHROID TRANSCRIPTIONAL FACTOR IN GM-CSF-DEPENDENT AND G-CSF-DEPENDENT MYELOID CELL-LINES
CROTTA, S
NICOLIS, S
RONCHI, A
OTTOLENGHI, S
RUZZI, L
SHIMADA, Y
MIGLIACCIO, AR
MIGLIACCIO, G
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (23) : 6863 - 6869
[4] THE HELA-CELL PROTEIN TEF-1 BINDS SPECIFICALLY AND COOPERATIVELY TO 2 SV40 ENHANCER MOTIFS OF UNRELATED SEQUENCE
DAVIDSON, I
XIAO, JH
ROSALES, R
STAUB, A
CHAMBON, P
[J]. CELL, 1988, 54 (07) : 931 - 942
[5] THE HUMAN BETA-GLOBIN PROMOTER - NUCLEAR-PROTEIN FACTORS AND ERYTHROID SPECIFIC INDUCTION OF TRANSCRIPTION
DEBOER, E
ANTONIOU, M
MIGNOTTE, V
WALL, L
GROSVELD, F
[J]. EMBO JOURNAL, 1988, 7 (13) : 4203 - 4212
[6] ACCURATE TRANSCRIPTION INITIATION BY RNA POLYMERASE-II IN A SOLUBLE EXTRACT FROM ISOLATED MAMMALIAN NUCLEI
DIGNAM, JD
LEBOVITZ, RM
ROEDER, RG
[J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (05) : 1475 - 1489
[7] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS
GORMAN, CM
MOFFAT, LF
HOWARD, BH
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (09) : 1044 - 1051
[8] STRUCTURE AND PROMOTER ACTIVITY OF THE GENE FOR THE ERYTHROID TRANSCRIPTION FACTOR GATA-1
HANNON, R
EVANS, T
FELSENFELD, G
GOULD, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) : 3004 - 3008
[9] ACTIVATION OF THE AIDS RETROVIRUS PROMOTER BY THE CELLULAR TRANSCRIPTION FACTOR, SP1
JONES, KA
KADONAGA, JT
LUCIW, PA
TJIAN, R
[J]. SCIENCE, 1986, 232 (4751) : 755 - 759
[10] THE EFFECTS OF HPFH MUTATIONS IN THE HUMAN GAMMA-GLOBIN PROMOTER ON BINDING OF UBIQUITOUS AND ERYTHROID SPECIFIC NUCLEAR FACTORS
MANTOVANI, R
MALGARETTI, N
NICOLIS, S
RONCHI, A
GIGLIONI, B
OTTOLENGHI, S
[J]. NUCLEIC ACIDS RESEARCH, 1988, 16 (16) : 7783 - 7797

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