THE USE OF T2-DISTRIBUTION TO STUDY TUMOR EXTENT AND HETEROGENEITY IN HEAD AND NECK-CANCER

被引：10

作者：

BLOCH, P

LENKINSKI, RE

BUHLE, EL

HENDRIX, R

BRYER, M

MCKENNA, WG

机构：

[1] Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia

[2] Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia

[3] Department of Otorhinolaryngology and Human Communication, University of Pennsylvania School of Medicine, Philadelphia

来源：

MAGNETIC RESONANCE IMAGING | 1991年 / 9卷 / 02期

关键词：

EXTENT OF TUMORS; HEAD AND NECK TUMORS; TUMOR HETEROGENEITY; MRI; T2-DISTRIBUTION;

D O I：

10.1016/0730-725X(91)90012-B

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Demarcation of the extent of malignant tissue is essential for planning a course of radiotherapy. MR images may provide additional information for delineating the target volume because of the large difference in the proton magnetic resonance relaxation times between normal and malignant tissues. In 13 patients with head and neck tumors the distribution of the proton spin-spin relaxation times, T2, at 1.5 Tesla were evaluated throughout the physician designated target volume and normal surrounding tissue. The T2 values within the tumor were always elevated compared with normal tissue, the highest values being in the nominal center of the tumor and decreasing toward the periphery. The regional distribution of T2 values within the tumor is a measure of the tissue heterogeneity within the tumor volume. In addition, the large differences in T2 relaxation times between normal and disease tissues were used in a computer algorithm to automatically demarcate the boundary of abnormal tissue in each axial MRI section. This potentially could significantly expedite the time required to identify the target volume on multiple sections and thus remove one of the major time constraints for 3D treatment planning.

引用

页码：205 / 211

页数：7

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