EFFECT OF OXYMETAZOLINE NOSE DROPS ON VASCULAR-PERMEABILITY OF THE NASAL-MUCOSA IN THE RABBIT AFTER PROVOCATION WITH LEUKOTRIENE-B4

被引：9

作者：

BENDE, M

HANSELL, P

INTAGLIETTA, M

ARFORS, KE

机构：

[1] Department of Applied Mechanics, Engineering Sciences-Bioengineering, University of California San Diego, La Jolla, CA

[2] La Jolla Institute for Experimental Medicine, University of California San Diego, La Jolla, CA

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES | 1992年 / 54卷 / 05期

关键词：

ADHESION; ALBUMIN; INFLAMMATION; LEUKOTRIENE-B4; NASAL MUCOSA; RABBIT; NEUTROPHIL; NOSE DROPS; OXYMETAZOLINE; PERMEABILITY;

D O I：

10.1159/000276313

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The effects of oxymetazoline nose drops on the vascular permeability of the nasal mucosa in a provoked inflammatory reaction was studied in anesthetized rabbits. Vascular permeability (I-125-albumin) was 53 % higher in the leukotriene B4-provoked nostril (LTB4) compared with the vehicle-treated contralateral nostril (p < 0.05). The amount of secretions was, however, not different from the vehicle-treated side. The LTB4-induced increase in permeability was decreased by 22 % when oxymetazoline was introduced (p < 0.05), and the amount of secretions was reduced by 22 % (p < 0.01). The effect of oxymetazoline on the vascular permeability of the nasal mucosa can be attributed to a vascular constriction (decrease in blood flow) and/or a change in the permeability characteristics. The LTB4-induced increase in vascular permeability was not attenuated by the monoclonal antibody IB4 directed against the neutrophil adhesion complex CD11/CD18. The latter suggests that LTB4-induced vascular permeability does not require CD18-mediated neutrophil adherence in the nasal mucosa.

引用

页码：270 / 274

页数：5

共 17 条

[1]

Petersson G., McCaffrey T.V., Malm L., Substance P and nasal secretion in dog, rat. and man, Ann Allergy, 62, pp. 410-414, (1989)

[2]

Udaka K., Takcuchi Y., Movat H.Z., Simple method for quantitation of enhanced vascular permeability, Proc Med, 133, pp. 1384-1387, (1970)

[3]

Bray M.A., Leukotrienes in inflammation, AgentsAction, 19, pp. 87-99, (1986)

[4]

Svensson C., Persson C.G.A., Baumgarten C.R., Alkner U., Pipkorn U., Topical alpha-adrenoceptor-stimulation may not reduce histamine-induced plasma leakage in human nasal airways, Clin Exp Allergy, 22, pp. 411-416, (1992)

[5]

Walden S.M., Proud D., Bascom R., Lichtenstein L.M., Kagey-Sobotka A., Adkinson N.F., Naclerio R.M., Experimentally induccd nasal allergic responses, J Immunol, 81, pp. 940-949, (1988)

[6]

Naclerio R.M., Meier H.L., Kagey-Sobotka A., Norman P.S., Lichtenstein L.M., In vivo model for the evaluation of topical antiallergic medications, Arch Otolaryngol, 110, pp. 25-27, (1984)

[7]

Naclerio R.M., The pathophysiology of allergic rhinitis: Impact of therapeutic intervention, J Immunol, 82, pp. 927-934, (1988)

[8]

Bende M., The effect of topical decongestants on blood flow in normal and infected nasal mucosa, Acta Otolaryngol (Stockh), 96, pp. 523-527, (1983)

[9]

Bende M., Loth S., Vascular effect of oxymeta-zoline on human nasal mucosa, J Laryngol Otol, 100, pp. 285-288, (1986)

[10]

Timmermans P.B.M.W.M., Signal transformation of alpha-adrcnoceptors, Recent Advances in Receptor Chemistry, (1988)

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