EFFECT OF THYROXINE ON THE ACTIVITY OF MITOCHONDRIAL CARDIOLIPIN SYNTHASE IN RAT-LIVER

被引：63

作者：

HOSTETLER, KY ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,DIV ENDOCRINOL & METAB,LA JOLLA,CA 92093

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1991年 / 1086卷 / 01期

关键词：

THYROID HORMONE; THYROXINE; CARDIOLIPIN SYNTHASE; MITOCHONDRION;

D O I：

10.1016/0005-2760(91)90165-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiolipin is a major mitochondrial membrane lipid and plays a vital role in mitochondrial function. The effect of thyroxine on the activity of liver mitochondrial cardiolipin synthase was examined in this study. Treatment with thyroxine (250-mu-g/100 g) for 5 days increased cardiolipin synthase activity by 52%. Mitochondrial levels of cardiolipin appear to be regulated in part by the effect of thyroid hormone on the activity of cardiolipin synthase.

引用

页码：139 / 140

页数：2

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