AMINOLYSIS OF 2'-DEOXYINOSINE ARYL ETHERS - NUCLEOSIDE MODEL STUDIES FOR THE SYNTHESIS OF FUNCTIONALLY TETHERED OLIGONUCLEOTIDES

被引：22

作者：

FERENTZ, AE ^{[1
]}

VERDINE, GL ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM,12 OXFORD ST,CAMBRIDGE,MA 02143

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 10期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1080/07328319208017821

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several O6-aryl-2'-deoxyinosines were synthesized and found to undergo conversion to N6-substituted-2'-deoxyadenosines upon treatment with aqueous amines. The kinetics for reaction of these nucleosides with various amines suggests that O6-phenyl- and O6-(p-nitrophenyl)-2'-deoxyinosine are suitable ''convertible nucleoside'' precursors for the site-specific introduction of functionally tethered 2'-deoxyadenosines into DNA.

引用

页码：1749 / 1763

页数：15

共 12 条

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