CLASTOGENIC EFFECT OF PESTICIDES IN PERIPHERAL LYMPHOCYTES OF COTTON-FIELD WORKERS

被引：44

作者：

RUPA, DS

REDDY, PP

REDDI, OS

机构：

[1] HOSP GENET DIS,INST GENET,HYDERABAD 16,ANDHRA PRADESH,INDIA

[2] TRANSGENE BIOTEK,INST MOLEC BIOL & BIOTECHNOL,HYDERABAD 34,ANDHRA PRADESH,INDIA

来源：

MUTATION RESEARCH | 1991年 / 261卷 / 03期

关键词：

PESTICIDES; CLASTOGENIC EFFECT; COTTON-FIELD WORKERS; PERIPHERAL LYMPHOCYTES;

D O I：

10.1016/0165-1218(91)90065-T

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We studied clastogenic effects in peripheral lymphocytes of cotton-field workers who were exposed to different pesticides. All the cells were grown in RPMI 1640 medium for 48 and 72 h. The type of aberrations observed in the exposed group are gaps, breaks. dicentrics, exchanges, rings and polyploidy. The frequency of total chromosomal aberrations increased significantly in male pesticide applicators when compared to controls. A significant decrease in mitotic index was observed in the exposed group as compared to the control group. The 48-h cultures showed high incidence of chromosomal aberrations and low mitotic index when compared to 72-h cultures. The difference in chromosomal aberrations between 48- and 72-h cultures was not significant. 24 out of 26 individuals showed ill health effects such as severe giddiness and nervous disorders.

引用

页码：177 / 180

页数：4

共 16 条

[1] SISTER-CHROMATID EXCHANGES AND CELL-CYCLE DELAY IN CHINESE HAMSTER-V79 CELLS TREATED WITH 9 ORGANO-PHOSPHORUS COMPOUNDS (8 PESTICIDES AND 1 DEFOLIANT) [J].