ION TRAP TANDEM MASS-SPECTROMETRIC EVIDENCE FOR THE METABOLISM OF 3,4-(METHYLENEDIOXY)METHAMPHETAMINE TO THE POTENT NEUROTOXINS 2,4,5-TRIHYDROXYMETHAMPHETAMINE AND 2,4,5-TRIHYDROXYAMPHETAMINE

被引:38
作者
LIM, HK
FOLTZ, RL
机构
[1] Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City
关键词
D O I
10.1021/tx00024a004
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:626 / 632
页数:7
相关论文
共 22 条
[1]   MDMA-INDUCED NEUROTOXICITY - PARAMETERS OF DEGENERATION AND RECOVERY OF BRAIN-SEROTONIN NEURONS [J].
BATTAGLIA, G ;
YEH, SY ;
DESOUZA, EB .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1988, 29 (02) :269-274
[2]   SPECIES VARIATION IN THE RESPONSE OF THE CYTOCHROME P-450-DEPENDENT MONOOXYGENASE SYSTEM TO INDUCERS AND INHIBITORS [J].
BOOBIS, AR ;
SESARDIC, D ;
MURRAY, BP ;
EDWARDS, RJ ;
SINGLETON, AM ;
RICH, KJ ;
MURRAY, S ;
DELATORRE, R ;
SEGURA, J ;
PELKONEN, O ;
PASANEN, M ;
KOBAYASHI, S ;
ZHIGUANG, T ;
DAVIES, DS .
XENOBIOTICA, 1990, 20 (11) :1139-1161
[3]   MELANIN AND ITS PRECURSORS .3. NEW SYNTHESES OF 5-6-DIHYDROXYINDOLE AND ITS DERIVATIVES [J].
BULOCK, JD ;
HARLEYMASON, J .
JOURNAL OF THE CHEMICAL SOCIETY, 1951, (SEP) :2248-2252
[4]   DERIVATIZATION OF CATECHOLAMINES IN AQUEOUS-SOLUTION FOR QUANTITATIVE-ANALYSIS IN BIOLOGICAL-FLUIDS [J].
DEJONG, APJM ;
CRAMERS, CA .
JOURNAL OF CHROMATOGRAPHY, 1983, 276 (02) :267-278
[5]  
ELAYAN IM, 1991, IN PRESS SOC NEUR AB
[6]   MPTP, THE NEUROTOXIN INDUCING PARKINSONS-DISEASE, IS A POTENT COMPETITIVE INHIBITOR OF HUMAN AND RAT CYTOCHROME-P450 ISOZYMES (P450BUFI, P450DB1) CATALYZING DEBRISOQUINE 4-HYDROXYLATION [J].
FONNEPFISTER, R ;
BARGETZI, MJ ;
MEYER, UA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (03) :1144-1150
[7]   CHARACTERIZATION OF THE COMMON GENETIC-DEFECT IN HUMANS DEFICIENT IN DEBRISOQUINE METABOLISM [J].
GONZALEZ, FJ ;
SKODA, RC ;
KIMURA, S ;
UMENO, M ;
ZANGER, UM ;
NEBERT, DW ;
GELBOIN, HV ;
HARDWICK, JP ;
MEYER, UA .
NATURE, 1988, 331 (6155) :442-446
[8]  
HIRAMATSU M, 1990, J PHARMACOL EXP THER, V254, P521
[9]   THE USE OF ALKOXYCARBONYL DERIVATIVES FOR THE MASS-SPECTRAL ANALYSIS OF DRUG THIOETHER METABOLITES - STUDIES WITH THE CYSTEINE, MERCAPTURIC ACID AND GLUTATHIONE CONJUGATES OF ACETAMINOPHEN [J].
HOFFMANN, KJ ;
BAILLIE, TA .
BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1988, 15 (12) :637-647
[10]  
JOHNSON M, 1991, IN PRESS SOC NEUR AB