INTERACTIONS BETWEEN PRESERVATIVES AND 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN

被引：47

作者：

LOFTSSON, T ^{[1
]}

STEFANSDOTTIR, O ^{[1
]}

FRIORIKSDOTTIR, H ^{[1
]}

GUOMUNDSSON, O ^{[1
]}

机构：

[1] STATE IMPORT DRUGS & MED,IS-125 REYKJAVIK,ICELAND

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 13期

关键词：

D O I：

10.3109/03639049209040853

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The interactions between several commonly used preservatives, i.e. benzalkonium chloride, chlorhexidine gluconate, chlorobutanol, methylparaben and propylparaben, and 2-hydroxypropyl-beta-cyclodextrin were investigated. The interactions were shown to be twofold. Firstly, the preservative molecules can displace the drug molecules from the cyclodextrin cavity, thus, reducing the solubilizing effects of the cyclodextrin. Secondly, the antimicrobial activity of the preservatives were reduced by formation of preservative-cyclodextrin inclusion complexes. The magnitude of the interactions were dependent on the degree of complexation.

引用

页码：1477 / 1484

页数：8