MULTIMERIZATION OF ICP0, A HERPES-SIMPLEX VIRUS IMMEDIATE-EARLY PROTEIN

被引:29
作者
CHEN, JX [1 ]
PANAGIOTIDIS, C [1 ]
SILVERSTEIN, S [1 ]
机构
[1] COLUMBIA UNIV,DEPT MICROBIOL,701 W 168TH ST,NEW YORK,NY 10032
关键词
D O I
10.1128/JVI.66.9.5598-5602.1992
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we provide evidence that the protein multimerizes. Some mutant forms of ICP0 were transdominant and interfered with activation of a target reporter gene or with complementation of an ICP0-minus virus.
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页码:5598 / 5602
页数:5
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