TRANSFORMING GROWTH-FACTOR-BETA-1 (TGF-BETA-1)- AND BETA-2-LIKE ACTIVITIES IN MALIGNANT PLEURAL EFFUSIONS CAUSED BY MALIGNANT MESOTHELIOMA OR PRIMARY LUNG-CANCER

被引：35

作者：

MAEDA, J ^{[1
]}

UEKI, N ^{[1
]}

OHKAWA, T ^{[1
]}

IWAHASHI, N ^{[1
]}

NAKANO, T ^{[1
]}

HADA, T ^{[1
]}

HIGASHINO, K ^{[1
]}

机构：

[1] HYOGO MED UNIV,DEPT INTERNAL MED 3,NISHINOMIYA,HYOGO 663,JAPAN

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 1994年 / 98卷 / 02期

关键词：

TGF-BETA-1; TGF-BETA-2; MALIGNANT PLEURAL EFFUSION; MALIGNANT MESOTHELIOMA; PRIMARY LUNG CANCER;

D O I：

10.1111/j.1365-2249.1994.tb06144.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the levels of TGF-beta in malignant pleural effusions (MPE) caused by malignant mesothelioma (MESO) or primary lung cancer. TGF-beta levels in MPE caused by MESO were 283.9 +/- 219.2 pM (mean +/- s.d.) and were three to six times higher than those due to primary lung cancers (P < 0.01 or P < 0.05). We also evaluated TGF-beta 1- and beta 2-like activities in MPE using specific polyclonal antibodies. Although TGF-beta 1-like activity could be detected in all cases, TGF-beta 2-like activities were detected in five of seven in MESO and in a few cases with primary lung cancer. These results demonstrate that the levels of total TGF-beta and TGF-beta 2-like activity may be clinically useful to differentiate MESO from primary lung cancer. Our data also suggest that TGF-beta may help further characterize the clinical features of MESO.

引用

页码：319 / 322

页数：4

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