ALTERNATE VIEW ON THERMAL-STABILITY OF THE DNA DUPLEX

被引：30

作者：

KUMAR, A

机构：

[1] Physical Chemistry Division, National Chemical Laboratory

来源：

BIOCHEMISTRY | 1995年 / 34卷 / 40期

关键词：

D O I：

10.1021/bi00040a001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A concept, based on the changes in internal pressure of water due to addition of salts, has been used to interpret the thermal stability of the DNA duplexes. Dependence of thermal stability of duplexes on the salt concentrations has also been described in terms of variations in the internal pressure of water observed in presence of ionic components. The thermal stabilities at high external pressures (up to 200 MPa) compared to those at atmospheric pressure are linearly related to the corresponding variations in internal pressures at several salt concentrations.

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页码：12921 / 12925

页数：5

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