TOTAL SYNTHESIS OF ARYL C-GLYCOSIDE ANTIBIOTICS

被引：46

作者：

SUZUKI, K

机构：

[1] Department of Chemistry, Keio University, 3-14-1 Hiyoshi

来源：

PURE AND APPLIED CHEMISTRY | 1994年 / 66卷 / 10-11期

关键词：

D O I：

10.1351/pac199466102175

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An approach to the regio- and stereocontrolled synthesis of aryl C-glycoside antibiotics is described. The key reaction is the Lewis acid-mediated formation of aryl O-glycosides and its in situ conversion to C-glycosides (O-->C-glycoside rearrangement). The utility of this reaction is demonstrated in the total syntheses of vineomycinone B2 (1) and gilvocarcin M (2) and V (3). The latter synthesis established the absolute stereochemistry of the gilvocarcins.

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页码：2175 / 2178

页数：4

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