TESTING OF IN-VITRO DISSOLUTION BEHAVIOR OF MICROPARTICULATE DRUG-DELIVERY SYSTEMS

被引：21

作者：

CONTI, B ^{[1
]}

GENTA, I ^{[1
]}

GIUNCHEDI, P ^{[1
]}

MODENA, T ^{[1
]}

机构：

[1] UNIV CATANIA,INST PHARMACEUT CHEM,I-95125 CATANIA,ITALY

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1995年 / 21卷 / 10期

关键词：

D O I：

10.3109/03639049509026671

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

No official dissolution method exists concerning microparticulate drug delivery systems. The purpose of this work is the evaluation of different dissolution methods commonly used to test the in vitro release behaviour of microparticulate drug delivery systems. The influence of different environmental conditions, as stirring speed, ionic strength and presence of surfactant, on drug release is also evaluated. Four dissolution methods, based on different equipments (USP dissolution test apparatus, rotating bottle apparatus, shaker incubator, recycling flow through cell), are performed on the same batch of indomethacin loaded poly-D,L-lactide (PDLLA) microspheres prepared by spray drying. The results obtained with the methods tested show the influence of in vitro dissolution method employed and of the environmental conditions on drug release profile

引用

页码：1223 / 1233

页数：11

共 14 条

[1] DEGRADABLE STARCH MICROSPHERES AS A NASAL DELIVERY SYSTEM FOR INSULIN [J].

BJORK, E ;

EDMAN, P .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 47 (1-3) :233-238

[2] THE EFFECT OF PH ON THE INVITRO DEGRADATION OF POLY(GLYCOLIDE LACTIDE) CO-POLYMER ABSORBABLE SUTURES [J].

CHU, CC .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1982, 16 (02) :117-124

[3] AN INVITRO EVALUATION OF THE STABILITY OF MECHANICAL-PROPERTIES OF SURGICAL SUTURE MATERIALS IN VARIOUS PH CONDITIONS [J].

CHU, CC ;

MONCRIEF, G .

ANNALS OF SURGERY, 1983, 198 (02) :223-228

[4]

Davis S. S., 1984, MICROSPHERES DRUG TH

[5]

ILLUM L, 1988, INT J PHARM, V46, P261

[6] UNIFORM AND IMPROVED BIOAVAILABILITY OF NEWLY DEVELOPED RAPID AND SUSTAINED-RELEASE SUSPENSIONS OF IBUPROFEN MICROSPHERES [J].

KAWASHIMA, Y ;

IWAMOTO, T ;

NIWA, T ;

TAKEUCHI, H ;

HINO, T .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1993, 89 (01) :9-17

[7] INVIVO ASSESSMENT OF SALMON-CALCITONIN SUSTAINED-RELEASE FROM BIODEGRADABLE MICROSPHERES [J].

LEE, KC ;

SOLTIS, EE ;

NEWMAN, PS ;

BURTON, KW ;

MEHTA, RC ;

DELUCA, PP .

JOURNAL OF CONTROLLED RELEASE, 1991, 17 (02) :199-205

[8]

LEHR CM, 1992, EUR J PHARM BIOPHARM, V38, P55

[9]

LIN F, 1984, BIOMEDICAL APPLICATI

[10]

MAHATO RI, 1992, 19TH P INT S CONTR R, P341

← 1 2 →