INFLUENCE OF TETRAETHYLAMMONIUM (TEA+), SH-COMPOUNDS AND INSULIN ON K'-RELEASE OF PHALLOIDIN-POISONED ISOLATED RAT LIVER

1. (1) K+-release in phalloidin-poisoned rat liver is inhibited by tetraethylammonium and several SH-compounds. 2. (2) Insulin does not diminish this K+-loss of the liver cell, when administered in physiological concentrations. Only very high doses inhibit the phalloidin-induced potassium release. 3. (3) In view of the findings on isolated liver cell membranes by Hegner et al. our results suggest that phalloidin is an iontophoretic substance like valinomycine and other antibiotics. Phalloidin seems to open potassium channels of the liver cell plasma membrane. © 1969.