FRACTIONAL FACTORIAL EXPERIMENTAL DESIGN STUDY OF IMCOMPATIBILITY OF BENZOCAINE IN THROAT LOZENGES

被引：9

作者：

KABASAKA.P

CANNON, G

PINCHUK, G

机构：

[1] Research and Development Division, Schering Corporation, Bloomfield, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Benzocaine incompatibility—lozenge excipients; Bratton and Marshall reaction—analysis; Fractional factorial design—benzocaine incompatibility; Lozenges—benzocaine instability;

D O I：

10.1002/jps.2600580106

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The instability of benzocaine in a throat lozenge formulation has been shown to be due to the reactivity of the primary aromatic amine group. Three common excipients of throat lozenges were found to be incompatible with benzocaine. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：45 / &

共 17 条

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