LEARNING-INDUCED CHANGE IN NEURAL ACTIVITY DURING ACQUISITION AND CONSOLIDATION OF A PASSIVE-AVOIDANCE RESPONSE IN THE RAT

被引:17
作者
DOYLE, E [1 ]
NOLAN, PM [1 ]
REGAN, CM [1 ]
机构
[1] NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT PHARMACOL,DUBLIN 4,IRELAND
关键词
amygdala; brainstem; deoxyglucose; memory/learning; passive avoidance; striatum;
D O I
10.1007/BF00966216
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Time-dependent alterations in neural activity have been established during the acquisition and consolidation of a stepdown passive avoidance paradigm. Change in neural activity was established by administering a glucose analogue, [3H]2-deoxyglucose, 50min prior to sacrifice and estimating perchloric acid soluble counts in nine hand dissected brain regions. Change in [3H]2-deoxyglucose uptake was closely paralleled in both trained and yoked animals for up to 40min following task acquisition however the striatum was the only area to exhibit a task-specific increase in [3H]2-deoxyglucose uptake at 20-30min after training. Longterm changes in neural activity were also apparent as the amygdala and brainstem showed increased [3H]2-deoxyglucose uptake at the 24h time point. No further paradigm-specific changes were apparent at 48 h. These findings are concluded to suggest that the striatum is involved in the early events of acquiring a passive avoidance response and the amygdala and brainstem during the later events. © 1990 Plenum Publishing Corporation.
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页码:551 / 558
页数:8
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