A NOVEL SYNTHESIS OF 1-AMINOALKYLPHOSPHONATES

被引：28

作者：

CHAKRABORTY, SK

ENGEL, R

机构：

[1] Department of Chemistry and Biochemistry, Queens College of the City, University of New York, Flushing

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 8-9期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1080/00397919108019793

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route has been devised for the preparation of a series of 1-aminoalkylphosphonate diesters, precursors to analogues of a-amino acids. The route involves a facile bromine substitution at the 1-position of alkylphosphonate diesters using N-bromosuccinimide, followed by azide ion displacement and catalytic hydrogenolysis.

引用

页码：1039 / 1046

页数：8

共 7 条

[1] ORGANO-PHOSPHORUS CHEMISTRY .2. THE REDUCTION OF QUINQUEVALENT PHOSPHORUS TO THE TRIVALENT STATE [J].