A CYCLIC-AMP-GATED CONDUCTANCE IN COCHLEAR HAIR-CELLS

被引：34

作者：

KOLESNIKOV, SS

REBRIK, TI

ZHAINAZAROV, AB

TAVARTKILADZE, GA

KALAMKAROV, GR

机构：

[1] ACAD SCI USSR,INST BIOL PHYS,MOSCOW 142292,USSR

[2] ACAD SCI USSR,INST CHEM PHYS,MOSCOW 117334,USSR

[3] ALL UNION AUDIOL & HLTH CTR,MOSCOW,USSR

来源：

FEBS LETTERS | 1991年 / 290卷 / 1-2期

关键词：

COCHLEAR HAIR CELL; CAMP-ACTIVATED CHANNEL; PATCH CLAMP TECHNIQUE;

D O I：

10.1016/0014-5793(91)81251-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The patch clamp technique was used to record cAMP-dependent currents of the guinea pig cochlear hair cell plasma membrane. Data obtained indicate that the channels passing this current are moderately selective for monovalent cations and are effectively blocked by L-cis diltiazem and reversibly blocked by 1 mM Mg2+ or Ca2+. The single-channel unit conductance estimated in the absence of divalent cations is about 16 pS. The results demonstrate that cyclic nucleotide-dependent channels of cochlear hair cells are virtually identical to the photoreceptor and olfactory ones.

引用

页码：167 / 170

页数：4

共 15 条

[1] TRANSDUCTION PHYSIOLOGY OF OLFACTORY RECEPTOR CILIA [J].